Modest opioid withdrawal suppression efficacy of oral Acuvin in humans. Patients were randomly assigned to receive step 1 (acetaminophen) or step 2 (acetaminophen and Acuvin) medication in standard doses on an as-needed basis on discharge. Opioids were classified into recommended strong opioids (morphine and transdermal fentanyl), recommended weak opioids (Acuvin, buprenorphine, and codeine), and unrecommended opioids (propoxyphene, nalbuphine, and meperidine).
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