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Tolterodine
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Tolterodine

Tolterodine is medication used to treat frequent urination, urinary incontinence, or urinary urgency. Effects are seen within an hour. It is taken by mouth.Common side effects include headache, dry mouth, constipation, and dizziness. Serious side effects may include angioedema, urinary retention, and QT prolongation. Use in pregnancy and breastfeeding are of unclear safety. It works by blocking muscarinic receptors in the bladder thus decreasing bladder contractions.Tolterodine was approved for medical use in 1998. It is available as a generic medication. A month supply costs the NHS about GB£2.09 per month as of 2019. In the United States the wholesale cost of this amount is about US$37.16. In 2016 it was the 300th most prescribed medication in the United States with more than a million prescriptions.

Other names for this medication:
Tolterodine, Detrol, Roliten, Detrusitol, Flochek,

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Tolterodine comes as a tablet and an extended-release (long-acting) capsule to take by mouth. The tablet is usually taken twice a day. The extended-release capsule is usually taken once a day with liquids. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tolterodine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the extended-release capsules whole; do not split, chew, or crush them.

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The malformation may resolve spontaneously obviating the need for intervention. We describe a 22-year-old woman in her 34th week of pregnancy in whom ultrasound revealed a cystic lesion 8 x 10 cm. Tumour tissue sampling for lung cancer management in the era of personalised therapy: what is good enough for molecular testing? Proportional hazards regression with time-varying covariates was used to model associations. 57 cases of papillary thyroid carcinoma were with lymph node metastasis.

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Nonoperative treatment of proximal femoral fractures in the demented, nonambulatory patient. TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20. This malaria immunoperoxidase assay is as sensitive as, and occasionally more sensitive than, the indirect fluorescent antibody assay. We conclude that these sex steroid receptors are not present in significant amounts to mediate a direct effect in basal carcinoma. The role of RAF in cell proliferation has been linked to its ability to activate mitogen-activated protein kinase kinase 1 (MEK) and mitogen-activated protein kinase 1 (ERK).

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Identification of a genomic locus containing three slow myosin heavy chain genes in the chicken. Role of cellular sodium and calcium metabolism in the pathogenesis of essential hypertension. The C-terminal tetrapeptide of beta-endorphin (MPF) enhances lymphocyte proliferative responses. To assess whether routine antibiotic prophylaxis before or immediately after incision or repair of episiotomy for women with an uncomplicated vaginal birth, compared with either placebo or no antibiotic prophylaxis, prevents maternal infectious morbidities and improves outcomes. Based on some ideas about the evolution of the underwater flight of penguins (part I) and morphological data obtained by dissection of 26 individuals (part II), a survey is developed about the cooperation and interaction of the components of the muscle apparatus and some ethological peculiarities of Penguins are explained by their anatomical basis.

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We used the human colon adenocarcinoma-derived cell line Caco-2, which spontaneously differentiates in vitro, as a model system to investigate the metabolism of 1 alpha,25-dihydroxycholecalciferol in colon cancer cells. Reading text increases binocular disparity in dyslexic children.

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The aim of the study was to determine the prevalence of burnout syndrome in Polish anaesthesiologists Spermatozoa of cholesterol-fed lxr-/- animals were found to be dramatically less viable and motile, and highly susceptible to undergo a premature acrosome reaction. Potential residual confounding from limited collection of comorbid condition, socioeconomic, and medication data.

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This study utilized primers from previous studies for detecting the mutation at position 1016 and newly designed primers to detect variants at position 1534. Woman in black: the cardiac ochronosis with severe aortic valve stenosis. Data from the 2010/11 Zimbabwe Demographic Health Survey (ZDHS), supplemented by additional data from the Measure DHS consultants were used.

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Erosive tooth wear, mainly on the mandibular first molars, was associated with age, high intake of sweet carbonated drinks, and xerostomia. Adenovirus type 12 DNA firmly associates with mammalian chromosomes early after virus infection or after DNA transfer by the addition of DNA to the cell culture medium. However, the evidence that some complications commonly attributed to diabetes mellitus occur in the context of transplantation lacks robustness. Maternal loading of a small heat shock protein increases embryo thermal tolerance in Drosophila melanogaster. Effect of coastal eutrophication on heavy metal bioaccumulation and oral bioavailability in the razor clam, Sinonovacula constricta.

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Dihydroergotamine and sumatriptan in isolated human coronary artery, middle meningeal artery and saphenous vein. Effect of colour LEDs on mycelia growth of Aspergillus ficuum and phytase production in photo-fermentations. To analyze the effectiveness of the hematology laboratory at detecting malignant fluids, this study retrospectively analyzed reports on 397 body fluid specimens (cerebrospinal, pericardial, peritoneal, and pleural) that were concurrently submitted over a 12-month period to both the cytopathology laboratory and the hematology laboratory. Upregulation of miR-513b inhibits cell proliferation, migration, and promotes apoptosis by targeting high mobility group-box 3 protein in gastric cancer. An 80-item questionnaire was mailed to the program directors of all accredited general surgery residencies in the United States.

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The Incidence of Rheumatic Infection in India: (As Judged by the Admission and Post-Mortem Rates and by the Clinical Experience of Teaching Physicians at the Medical Colleges and Schools of India). The results of experiments also suggest that the interaction between neuroendocrine and immune systems might take place on the level of some of above mentioned anatomical structures. Endorectal MRI was performed in 31 patients with histologically-proven prostate cancer. AFLP fingerprints were made from single zoospore progeny and 73 F1 progeny from two field isolates of P.

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Humanization of rhLCV with EBV gp350 also confers susceptibility to a potent EBV-neutralizing MAb and provides a novel and significant enhancement to the rhesus macaque animal model where both the clinical utility and biological role of neutralizing MAbs against B cell or epithelial cell infection can now be directly tested in the most accurate animal model for EBV infection. This new extension to metapopulation theory introduces an important tool for the management and conservation of migratory species and may also be applicable to model the dynamics of two host-parasite systems.

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Also, issues relating to the reliability of fMRI for listeners with normal hearing need to be resolved before this technique can be used to study listeners with hearing loss. The spatial distribution, movement, and impact of the untreated wastewater outfall from McMurdo Station, Antarctica, were investigated under early austral summer conditions. Characterization of an unstable allele of the Arabidopsis HY4 locus.

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Efficacy of hormone therapy in the mental disturbances of a patient with latent hypothyroidism Potassium channel dysfunction underlies Purkinje neuron spiking abnormalities in spinocerebellar ataxia type 2. The analysis also suggests that there is a relationship between gender DIF and item format. Protocols described in the literature have been vague, have used unstable landmarks, or have required several software programs, file conversions, or hand tracings, among other factors that could compromise the precision of the measurements.

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Challenges that remain include navigating immune responses, developing drugs capable of crossing the blood-brain barrier (BBB), developing therapies that can reverse end-organ damage, and achieving these goals in a safe, ethical, and financially sustainable manner. As the cells oriented to the underlying topography, the volume of the nucleus increased as the pitch of the topography increased from 400 nm to 2000 nm. Feasibility of 18F-FDG PET as a noninvasive diagnostic tool of muscle denervation: a preliminary study. Helicobacter pylori genotyping from American indigenous groups shows novel Amerindian vacA and cagA alleles and Asian, African and European admixture. A close agreement was found between the two methods of measuring Crs in the ten infants in whom a direct comparison was possible.

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Comparison of different hypo-osmotic swelling solutions to select viable immotile spermatozoa for potential use in intracytoplasmic sperm injection. Do antidepressants work in patients with chronic obstructive pulmonary disease with comorbid depression? We aim to review the safety and efficacy of these drugs in patients with CKD presenting with ACS.

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